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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Proteomics, Lymphocyte Population in Multiple Sclerosis and Disability
 Pavelek, Zbyšek ; Vališ, Martin (advisor) ; Mareš, Jan (referee) ; Hradílek, Pavel (referee)
Introduction Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease affecting the central nervous system. Although research on the diagnosis and treatment of this serious illness has made significant advances, the MS etiology remains unknown. Although there is still much to be found in the MS pathogenetic mechanisms, understanding the mechanisms of immune-mediated damage to the central nervous system (CNS) components of MS allows not only the introduction of new drugs that positively modulate inflammatory inflammation but also the understanding of immune- mediated diseases affecting the CNS in a broader sense. Methods The Ph.D. thesis is a general introduction followed by an annotated set of author's publications on proteomics, lymphocytic population in MS and disability. Study 1: Proteomic analysis of cerebrospinal fluid for relapsing-remitting multiple sclerosis and clinically isolated syndrome was conducted to find changes in the low molecular cerebrospinal fluid (CSF) segment and to determine what native peptides and how much they are in cerebrospinal fluid among patients with clinically isolated syndrome (CIS) and relapsing-MS (RR MS) compared to a healthy population. Study 2: Lymphocytes in the treatment with interferon beta-1b targeted individual...
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